Evaluation of cutaneous drug reactions in patients visiting out patient departments of Indira Gandhi Government Medical College and Hospital (IGGMC and H), Nagpur

Objectives: To detect cutaneous drug reactions through spontaneous reporting system in IGGMCand H, Nagpur and analyze them using standard assessment scales.Materials and Methods: An observational, prospective study was performed in patients attending dermatology OPD of IGGMC and H, Nagpur from 1 st June 05 to 31 st May 09.Patients were examined for cutaneous drug reactions (CDRs) by spontaneous Adverse Drug Reaction reporting system.Results: Among 2693 total ADRs john tory hair reported, 872 (33.

04%) were CDRs.Antimicrobials (55.5%) were the main drugs involved followed by NSAIDs (18.56%) and steroids (12.

61%).Maculopapular rash (37.73%) followed by fixed drug eruption (17.2%) and urticaria (14.

56%) were the most frequently observed CDRs.The common drugs causing CDRs were cotrimoxazole (20.41%), topical steroids (betamethasone), ibuprofen (7.91%), ampicillin (6.

54%), diclofenac (4.7%) and iron dextran (3.44%).Conclusion : It was observed that lintusakset commonly used drugs like antibiotics and NSAIDs lead to maximum number of CDRs.

Hence strict vigilance is required while using them.This study provides a database of ADRs due to common drugs, which will help clinicians in safe use of these drugs.

Leave a Reply

Your email address will not be published. Required fields are marked *